Integrations in and out of feed will encounter problems with duplicates on product numbers.
Integration into feed will fail on products with duplicate product numbers in feed.
Outgoing Integrations from feed with duplicates will likely not fail, but overwrite data in the receiving system by alternating between the feed products it exports from feed.
For this reason, we specifically support searches to find duplicates in feed on the Product number field (and the Alternative product number).
After the above exercise is completed and duplicates are cleaned up, there is still a risk of creating more duplicates later on.
You can prevent this by setting the product number as UNIQUE in feed.
Under Settings - Settings - Product settings, you can activate UNIQUE to prevent creating new products/bases/variants with duplicate product numbers.